This Biochemist Who Discovered EPO Has Had a Tremendous Impact on Thousand Oaks

Last Friday, Eugene Goldwasser died at his home in Chicago at the age of 88. While Eugene Goldwasser is not exactly well known by the general public, his greatest accomplishment changed the course of the biotech industry and the world in 1977 when he isolated the human protein erythropoietin "EPO."

EPO stimulates the production of red blood cells. It is a blockbuster product with over $5 billion in annual revenues for local Amgen because it has changed the lives of millions of dialysis patients and others suffering anemia due to the effects of other diseases. Without Eugene Goldwasser, Thousand Oaks and Ventura County most likely would be much different today, as Amgen employs roughly 10,000 people locally in 4 million square feet of office space! Amgen is the largest private employer in Ventura County today!

It took Goldwasser 20 years to isolate EPO, starting in 1957, when he discovered EPO in minute quantities of anemic rats (now that sounds like fun).

Then by 1971 his lab purified six millionths of an ounce of EPO from 125 gallons of plasma from anemic sheep.

In 1973 a Japanese anemia doctor collected 673 gallons of urine from his anemic patients. (I think someone should have told Mike Rowe, The Dirty Jobs guy, but he was only 11 years old at the time.) From that pee, Goldwasser's team isolated eight milligrams of EPO and perked up anemic rats like a charm!

Seeing the huge unmet need of EPO, the next step was to clone the gene and produce it in enough quantities to create a drug. Local Amgen scientist Fu-Kuen Lin and his lab figured this out in two years and the rest is history. Amgen figured out how to manufacture the drug by propagating the cells in a fermentation process (Kirin Brewery helped them on this!) and starting selling it under brand name Epogen in 1989.  It was Amgen's first drug and it was and still is a blockbuster.

The Sun is Back Out, at Least Temporarily! My Five Favorite Sunny Day Songs!

It has been raining for over a week almost non-stop here in Ventura County, but today, Christmas Eve Eve, we have a reprieve (well maybe for a couple days). The sunshing brings to mind these five sunny day songs that are tops on my list. My kids' personal favorite is Johnny Nash's original 1972 hit "I Can See Clearly Now." The Beatles are awesome but John Denver's "Sunshine on My Shoulder" gets my personal nod.

Local Simi Valley Family Dances Around Disneyland

Friends of mine from Simi Valley recently spent 2 days at Disneyland and Tony Pinto took the opportunity to use his little Flip Video Camera to make this entertaining video. His whole clan enjoyed dancing around highlights of the park, which must have been quite interesting to watch given they were not dancing to real music.  Brought a smile to my face.

Music: "Holiday" by Vampire Weekend

Why Are There No Ventura County Cities on MONEY Magazine's America's 100 Best Small Cities List?

The August 2010 issue of MONEY Magazine published its annual list of "100 Best Places to Live in America." I have subscribed to MONEY for years and each year my wife reviews the list and tells me 3 other places she would like to consider moving to. To which I reply:

I LIKE IT WHERE WE LIVE!

Curious, I reviewed MONEY's 2010 list and there was not a single Ventura County city on it.

MONEY's methodology was to start out with the 746 U.S. cities with a population of 50,000 to 300,000*, remove median incomes greater than 200% or below 85% of the state median, retirement communities, large job losses and poor education scores, then rank the remaining cities based on housing affordability, education, arts/leisure, health care, safety and other factors. *This methodology eliminates fine cities like Agoura and Moorpark from consideration.

Then they whittle down the list based on economic factors and visit 30 of the cities to select the winner.

Thousand Oaks, Simi Valley, Camarillo and Oxnard, all cities between 50,000 and 300,000, are nowhere to be found on the list.

I looked back at MONEY's Top 100 lists going back to 2005 and only once, Simi Valley in 2006 (#35), has a Ventura County city been included on this list. Something ain't right here!

Well it should be noted that Newbury Park, albeit not officially a city (it is part of Thousand Oaks), made it to #71 on the 2005 list. But that was 5 years ago!

Why is it that cities like Piscataway, NJ, Centreville, VA, Roswell, GA and Stillwater, OK made the list but not a single city from Ventura County has made the list  going back to 2006!?

MONEY, are you reading this? Come visit Ventura County why doncha and check out what we have to offer! Yah, all right, it is still a bit pricey to live here, but we have hundreds of things to do and all sorts of local events year round,  kids' activities and plenty more!

No offense, but I'm not leaving the Conejo Valley for Owensboro, KY, Gilbert, AZ, O'Fallon, MO or Millcreek, PA any time soon. I'm staying put right here in America's #1 county, Ventura County! :>

For the record though, here are the top 10 cities on the 2010 list: Eden Prairie, MN, Columbia/Ellicott City, MD, Newton, MA, Bellevue, WA, McKinney, TX, Fort Collins, CO, Overland Park, KS, Fishers, IN, Ames, IA and Rogers, AZ.

The Sun Was Beaming on the Thousand Oaks Civic Arts Plaza Today

Local resident Sarah Roth was visiting the beautiful Gardens of the World with her family today when she took this photo of the Thousand Oaks Civic Arts Plaza across the street. It looks like a sunbeam coming out of the sky! It was a perfect fall day after a night of light rain, with highs in the mid to upper 60s. Yet another great day to be out and about in the Conejo Valley.